After taking the medicine, I found that I was pregnant. Should this child have it?

Case introduction

Patients: Zhang, female, 28 years old, pneumonia (I don’t know she is pregnant).

Drug usage: 0.2g of sodium chloride injection of lactic acid cyclolar oleenia, quiet drip, 0.2g each time, 2 times a day for a total of 7 days.

After the disease was good, I found that menstruation was not coming, and it was confirmed that she was pregnant after being checked.

After the patient’s instructions, the patient learned that Cisciosa -star will affect the development of fetal cartilage, and pregnant women are disabled!

Q: Do children stay or not?

In this case, how to answer the patient’s consultation?

1. The confirmed human teratogenic medicine

Many drugs are related to abnormal fetuses, but only some drug cases are deformed.The following table lists drugs that have been confirmed to human beings.

Second, human embryo development sensitive period

After the eggs are fertilized, the development of embryos and fetus is divided into three stages: non -sensitive period, sensitive period and low sensitivity period.

1. During the non -sensitive period (early embryo): 14 to 28 days after the last menstruation, that is, 0 to 2 weeks of pregnancy.

During this period, the effect of drugs on the embryo is "all or no": either the embryo died (abortion) due to the impact of the death dose drugs, or the fetus was not affected by the drug, which would generally not cause fetal malformation.

2. Sensitive period (embryo period): 29 to 70 days after the last menstruation, 3-8 weeks of pregnancy.

During this period, it is a period of differentiation of fetal organs, such as central nervous system (brain), circulatory system (heart), sensory system (eye, ear), muscle skeletal system (limbs), etc.During this period, embryos are the most sensitive to drugs and prone to severe malformations.

3. Low sensitive period (fetal period): 9-38 weeks of pregnancy (11-40 weeks of pregnancy).

This period is a period of occurrence and functional maturity of most organizations.The impact of drugs may involve growth and function, such as mental development and reproductive function.

Three elements of risk assessment during pregnancy during pregnancy

At least the following three issues need to be known during the risk assessment of pregnancy.

1. What is the time to use the last menstrual period?

The time of the pregnant woman’s medication is from the last menstrual period: 23 to 29 days.

2. How long is the usual menstrual cycle?

The patient’s menstrual cycle is 28 days and is more regular.Under normal circumstances, women have ovulated 14 days after the last menstruation.

3. The nature of the drug (the effect of the drug on the fetus)?

Cisabinestar (antibacterial drugs) can be passed through the placenta barrier.The pregnancy safety of the US Food and Drug Administration (FDA) is C -Class.

Women during pregnancy are disabled!

Fourth, the risk assessment of pregnant women in the case

1. Last medication time: Is it in a non -sensitive period, or a sensitive period, or a low -sensitive period?

This pregnant woman is more special, and the medication time is 23 to 29 days after the last menstruation.The last time the medication was on the 29th day after the last menstrual period, and it crossed the relative safety period (not sensitive period) within 28 days.

2. Drug nature: half -life, reproductive toxicity, toxic target organs of drugs?

● half -life

The half -life of Cisabine is about 4-6 hours.In other words, after 6 semi -half -life (24 ~ 36 hours, about 2 days), Sipon Star is basically removed by 99%.

The last time the pregnant woman’s medication was on the 29th day after the last menstrual period, that is, the pregnant woman’s actual exposure was 31 days (29 days+2 days).

● Reproductive toxicity

Animal experiments have not confirmed the teratogenic effect of noserone drugs.

57 women who applied penoneone drugs and 17,259 cases of queue studies against women did not find the risk of increasing congenital abnormalities.

● Toxic target organs

Although animal experiments have not been confirmed to have teratogenic effects, they can cause joint animal joints.

After the formation of fertilized eggs, the muscle skeletal system starts within 4.33 weeks to 7 weeks (38-63 days after the last menstrual period).(See table below)

The pregnant woman was exposed to Cisabine for 31 days, and it was still 7 days before 38 days.Therefore, it can be judged: Since the Cisabine star has been cleared in the body, the impact on the fetus will be relatively small or not.

Evaluation suggestions:

From the perspective of pharmacy, according to the above medication time, after the drug is cleared, the fetus has not yet begun to develop bone development and can continue pregnancy. However, if there is a risk of abortion or bleeding, do not protect the fetus.

Kind tips:

Numeric women who do not take contraceptive measures during sexual life are using antiviral drugs (Libavarin), antibacterium antibacterial drugs (levofloxacin, ciprobine star, Moishastar, etc.), amino glycopide antibacterial drugs (amikaBefore the stars, galcinin, etc.), tetracycline antibacterial drugs (Minonlan, etc.), it is recommended to conduct pregnancy tests!

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Baby Scale-(24inch)